The compounds presented are investigational or are being investigated for uses that have not been approved by the US Food and Drug Administration (FDA), European Medicines Agency (EMA), or other health authorities.
ASCO 2025
Abstracts Supported by Bayer
May 30- June 3, 2025
Agenda of oral and poster presentations at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting
Please see below to download a PDF for each presentation and view a video (where applicable). Access for each publication will be available after the congress presentation.
Please select a compound to navigate to all related publications.
DAROLUTAMIDE
Substudy C of the Canadian cancer trials group (CCTG) IND.234: PC_BETS (Prostate Cancer Biomarker Enrichment and Treatment Selection)—A phase II study of darolutamide (DARO) selected by androgen-receptor (AR) circulating tumor DNA (ctDNA) in patients (PTS) with metastatic castration-resistant prostate cancer (mCRPC) after prior AR pathway inhibitors (ARPIs)
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Michael Ong
Poster Board Number #:
255
Darolutamide plus androgen deprivation therapy (ADT) in patients with high-risk biochemical recurrence (BCR) of prostate cancer: A phase 3, randomized, double-blind, placebo-controlled study (ARASTEP)
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Alicia K. Morgans
Poster Board Number #:
319B
Prognostic significance of PSA>0.2 after 6-12 months treatment for metastatic hormone-sensitive prostate cancer (mHSPC) intensified by androgen-receptor pathway inhibitors (ARPI): A multinational real-world analysis of the IRONMAN registry
Date/Time:
Tuesday, June 3, 2025 | 10:33 AM – 10:45 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Oral Abstract Session
Presenting Author:
Michael Ong
Abstract Number #:
5002
Larotrectinib resistance in TRK fusion cancers: Analysis of a tumor-agnostic, global clinical trial dataset
Date/Time:
Monday, June 2, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Type:
Poster Session
Presenting Author:
Alexander E Drilon
Poster Board Number #:
381
Efficacy and safety of larotrectinib in patients with non-primary central nervous system TRK fusion cancer: An updated analysis
Date/Time:
Monday, June 2, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Type:
Poster Session
Presenting Author:
Rui-Hua Xu
Poster Board Number #:
463
RADIUM-223
A multicenter, randomized, phase 2, investigator-initiated ETCTN trial of olaparib + radium-223 vs. radium-223 in men with castration-resistant prostate cancer (CRPC) with bone metastases (BM) (COMRADE): Initial efficacy and biomarker analysis
Date/Time:
Tuesday, June 3, 2025 | 11:57 AM – 12:09 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Session Type:
Oral Abstract Session
Presenting Author:
Rana R. McKay
Abstract Number #:
5007
Long-term safety of radium-223 (Ra-223) in metastatic castration-resistant prostate cancer (mCRPC): 7-year follow-up from the largest global prospective study
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Alton Oliver Sartor
Poster Board Number #:
247
PSA and alkaline phosphatase changes in the EORTC-1333 PEACE-3 study evaluating the addition of six cycles of radium 223 in metastatic castration-resistant prostate cancer (mCRPC) starting enzalutamide
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Andrey Soares
Poster Board Number #:
261
The impact of DNA repair genetic alterations identified by circulating tumor DNA on sensitivity to radium-223 in bone metastatic, castration-resistant prostate cancer
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Steven M. Blinka
Poster Board Number #:
314A
A phase l and randomized phase ll trial of radium-223 dichloride, peposertib, and avelumab in advanced metastatic castrate-resistant prostate cancer (mCRPC): Phase l results
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Hiram Alberto Gay
Poster Board Number #:
268
TKI
Panitumumab retreatment followed by regorafenib versus the reverse sequence in chemorefractory metastatic colorectal cancer patients with RAS and BRAF wild-type circulating tumor DNA (ctDNA): Results of the phase II randomized PARERE trial by GONO
Date/Time:
Sunday, June 1, 2025 | 12:00 PM – 12:06 PM CDT
Session:
Gastrointestinal Cancer—Colorectal and Anal
Session Type:
Rapid Oral Abstract Session
Presenting Author:
Chiara Cremolini
Abstract Number #:
LBA3515
Phase Ib study of the combination of regorafenib with conventional chemotherapy in patients with newly diagnosed multi-metastatic Ewing sarcoma: The Rego-Inter-Ewing-1 study
Date/Time:
Saturday, May 31, 2025 | 5:24 PM – 5:36 PM CDT
Session:
Pediatric Oncology I
Session Type:
Oral Abstract Session
Presenting Author:
Pablo Berlanga
Abstract Number #:
10008
A phase 1, first-in-human study of regorafenib plus temozolomide with or without radiotherapy in patients with newly diagnosed MGMT methylated, IDHwt glioblastoma: The REGOMA-2 trial
Date/Time:
Saturday, May 31, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Central Nervous System Tumors
Type:
Poster Session
Presenting Author:
Marta Padovan
Poster Board Number #:
114
Evaluation of the combination of regorafenib + avelumab in patients with non-small cell lung cancer without oncogenic addiction: The phase II REGOMUNE study
Date/Time:
Saturday, May 31, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Lung Cancer—Non-Small Cell Metastatic
Type:
Poster Session
Presenting Author:
Sophie Cousin
Poster Board Number #:
29
Regorafenib versus local standard of care in patients with grade 2-3 meningioma no longer eligible for loco-regional treatments: The MIRAGE trial
Date/Time:
Saturday, May 31, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Central Nervous System Tumors
Type:
Poster Session
Presenting Author:
Giuseppe Lombardi
Poster Board Number #:
141A
Combining low-dose regorafenib with pembrolizumab as a front-line therapy for patients with MSI-H colorectal cancer: REGPEM-CRC-01
Date/Time:
Saturday, May 31, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Gastrointestinal Cancer—Colorectal and Anal
Type:
Poster Session
Presenting Author:
Ibrahim Halil Sahin
Poster Board Number #:
307A
Myeloablative fractionated busulfan conditioning regimen with sorafenib for allogeneic stem cell transplant in AML: Results of a phase 1/2 study
Date/Time:
Sunday, June 1, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant
Type:
Poster Session
Presenting Author:
Uday Popat
Poster Board Number #:
177
Combined RAF- and MEK-inhibition in solid cancers with kinase-impaired BRAF mutations (SORATRAM phase I trial)
Date/Time:
Monday June 2, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Type:
Poster Session
Presenting Author:
Anna Lena Illert
Poster Board Number #:
434
Evaluation of longitudinal image-derived AI prognostication as a predictor of overall survival (OS) in a phase 3 advanced non-small cell lung cancer (aNSCLC) trial
Date/Time:
Sunday, June 1, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Care Delivery/Models of Care
Type:
Poster Session
Presenting Author:
Omar Farooq Khan
Poster Board Number #:
318
BAY 2927088
SOHO-01: Safety and efficacy of BAY 2927088 in patients with advanced HER2-mutant non-small cell lung cancer (NSCLC) who were pretreated but naïve to HER2-targeted therapy or had not received any treatment for advanced disease
Date/Time:
Sunday, June 1, 2025 | 9:12 AM – 9:24 AM CDT
Session:
Lung Cancer—Non-Small Cell Metastatic
Session Type:
Oral Abstract Session
Presenting Author:
Herbert H. Loong
Abstract Number #:
8504
panSOHO: Phase II trial of BAY 2927088 in patients with unresectable or metastatic solid tumors other than NSCLC with HER2‑activating mutations
Date/Time:
Monday, June 2, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Type:
Poster Session
Presenting Author:
Vivek Subbiah
Poster Board Number #:
486A
DAROLUTAMIDE
Substudy C of the Canadian cancer trials group (CCTG) IND.234: PC_BETS (Prostate Cancer Biomarker Enrichment and Treatment Selection)—A phase II study of darolutamide (DARO) selected by androgen-receptor (AR) circulating tumor DNA (ctDNA) in patients (PTS) with metastatic castration-resistant prostate cancer (mCRPC) after prior AR pathway inhibitors (ARPIs)
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Michael Ong
Poster Board Number #:
255
Darolutamide plus androgen deprivation therapy (ADT) in patients with high-risk biochemical recurrence (BCR) of prostate cancer: A phase 3, randomized, double-blind, placebo-controlled study (ARASTEP)
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Alicia K. Morgans
Poster Board Number #:
319B
Prognostic significance of PSA>0.2 after 6-12 months treatment for metastatic hormone-sensitive prostate cancer (mHSPC) intensified by androgen-receptor pathway inhibitors (ARPI): A multinational real-world analysis of the IRONMAN registry
Date/Time:
Tuesday, June 3, 2025 | 10:33 AM – 10:45 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Oral Abstract Session
Presenting Author:
Michael Ong
Abstract Number #:
5002
Larotrectinib resistance in TRK fusion cancers: Analysis of a tumor-agnostic, global clinical trial dataset
Date/Time:
Monday, June 2, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Type:
Poster Session
Presenting Author:
Alexander E Drilon
Poster Board Number #:
381
Efficacy and safety of larotrectinib in patients with non-primary central nervous system TRK fusion cancer: An updated analysis
Date/Time:
Monday, June 2, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Type:
Poster Session
Presenting Author:
Rui-Hua Xu
Poster Board Number #:
463
RADIUM-223
A multicenter, randomized, phase 2, investigator-initiated ETCTN trial of olaparib + radium-223 vs. radium-223 in men with castration-resistant prostate cancer (CRPC) with bone metastases (BM) (COMRADE): Initial efficacy and biomarker analysis
Date/Time:
Tuesday, June 3, 2025 | 11:57 AM – 12:09 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Session Type:
Oral Abstract Session
Presenting Author:
Rana R. McKay
Abstract Number #:
5007
Long-term safety of radium-223 (Ra-223) in metastatic castration-resistant prostate cancer (mCRPC): 7-year follow-up from the largest global prospective study
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Alton Oliver Sartor
Poster Board Number #:
247
PSA and alkaline phosphatase changes in the EORTC-1333 PEACE-3 study evaluating the addition of six cycles of radium 223 in metastatic castration-resistant prostate cancer (mCRPC) starting enzalutamide
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Andrey Soares
Poster Board Number #:
261
The impact of DNA repair genetic alterations identified by circulating tumor DNA on sensitivity to radium-223 in bone metastatic, castration-resistant prostate cancer
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Steven M. Blinka
Poster Board Number #:
314A
A phase l and randomized phase ll trial of radium-223 dichloride, peposertib, and avelumab in advanced metastatic castrate-resistant prostate cancer (mCRPC): Phase l results
Date/Time:
Monday, June 2, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Genitourinary Cancer—Prostate, Testicular, and Penile
Type:
Poster Session
Presenting Author:
Hiram Alberto Gay
Poster Board Number #:
268
TKI
Panitumumab retreatment followed by regorafenib versus the reverse sequence in chemorefractory metastatic colorectal cancer patients with RAS and BRAF wild-type circulating tumor DNA (ctDNA): Results of the phase II randomized PARERE trial by GONO
Date/Time:
Sunday, June 1, 2025 | 12:00 PM – 12:06 PM CDT
Session:
Gastrointestinal Cancer—Colorectal and Anal
Session Type:
Rapid Oral Abstract Session
Presenting Author:
Chiara Cremolini
Abstract Number #:
LBA3515
Phase Ib study of the combination of regorafenib with conventional chemotherapy in patients with newly diagnosed multi-metastatic Ewing sarcoma: The Rego-Inter-Ewing-1 study
Date/Time:
Saturday, May 31, 2025 | 5:24 PM – 5:36 PM CDT
Session:
Pediatric Oncology I
Session Type:
Oral Abstract Session
Presenting Author:
Pablo Berlanga
Abstract Number #:
10008
A phase 1, first-in-human study of regorafenib plus temozolomide with or without radiotherapy in patients with newly diagnosed MGMT methylated, IDHwt glioblastoma: The REGOMA-2 trial
Date/Time:
Saturday, May 31, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Central Nervous System Tumors
Type:
Poster Session
Presenting Author:
Marta Padovan
Poster Board Number #:
114
Evaluation of the combination of regorafenib + avelumab in patients with non-small cell lung cancer without oncogenic addiction: The phase II REGOMUNE study
Date/Time:
Saturday, May 31, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Lung Cancer—Non-Small Cell Metastatic
Type:
Poster Session
Presenting Author:
Sophie Cousin
Poster Board Number #:
29
Regorafenib versus local standard of care in patients with grade 2-3 meningioma no longer eligible for loco-regional treatments: The MIRAGE trial
Date/Time:
Saturday, May 31, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Central Nervous System Tumors
Type:
Poster Session
Presenting Author:
Giuseppe Lombardi
Poster Board Number #:
141A
Combining low-dose regorafenib with pembrolizumab as a front-line therapy for patients with MSI-H colorectal cancer: REGPEM-CRC-01
Date/Time:
Saturday, May 31, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Gastrointestinal Cancer—Colorectal and Anal
Type:
Poster Session
Presenting Author:
Ibrahim Halil Sahin
Poster Board Number #:
307A
Myeloablative fractionated busulfan conditioning regimen with sorafenib for allogeneic stem cell transplant in AML: Results of a phase 1/2 study
Date/Time:
Sunday, June 1, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant
Type:
Poster Session
Presenting Author:
Uday Popat
Poster Board Number #:
177
Combined RAF- and MEK-inhibition in solid cancers with kinase-impaired BRAF mutations (SORATRAM phase I trial)
Date/Time:
Monday June 2, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Type:
Poster Session
Presenting Author:
Anna Lena Illert
Poster Board Number #:
434
Evaluation of longitudinal image-derived AI prognostication as a predictor of overall survival (OS) in a phase 3 advanced non-small cell lung cancer (aNSCLC) trial
Date/Time:
Sunday, June 1, 2025 | 9:00 AM – 12:00 PM CDT
Session:
Care Delivery/Models of Care
Type:
Poster Session
Presenting Author:
Omar Farooq Khan
Poster Board Number #:
318
BAY 2927088
SOHO-01: Safety and efficacy of BAY 2927088 in patients with advanced HER2-mutant non-small cell lung cancer (NSCLC) who were pretreated but naïve to HER2-targeted therapy or had not received any treatment for advanced disease
Date/Time:
Sunday, June 1, 2025 | 9:12 AM – 9:24 AM CDT
Session:
Lung Cancer—Non-Small Cell Metastatic
Session Type:
Oral Abstract Session
Presenting Author:
Herbert H. Loong
Abstract Number #:
8504
panSOHO: Phase II trial of BAY 2927088 in patients with unresectable or metastatic solid tumors other than NSCLC with HER2‑activating mutations
Date/Time:
Monday, June 2, 2025 | 1:30 PM – 4:30 PM CDT
Session:
Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Type:
Poster Session
Presenting Author:
Vivek Subbiah
Poster Board Number #:
486A
